This literature review and issue of NASET’s Inclusion series was written by Madelyn Llaneras. It explores the role of advocacy and family involvement in supporting the academic and social success of students with Down syndrome. It highlights the crucial roles played by family involvement in facilitating the well-being of these students in both academic and social domains. The review commences by providing an overview of Down syndrome, its prevalence, characteristics, and its impact on learning. Subsequently, it delves into the academic challenges these students face in school and examines diverse interventions to improve their academic performance. Social challenges, including communication difficulties and establishing friendships, are also discussed. The review then explores practical approaches to help students with Down syndrome develop positive social skills.