People with osteogenesis imperfecta (OI) have bones that fracture easily, low muscle mass, and joint and ligament laxity. There are four major types of OI ranging in severity from mild to lethal. The appearance of people with OI varies considerably. Individuals may also have a blue or gray tint to the sclera (whites of the eyes), thin skin, growth deficiencies, and fragile teeth. They may develop scoliosis, respiratory problems, and hearing loss. Also known as "brittle bone disease," this disorder arises from mutations in the two genes that make type I collagen, a protein important to bones and skin.
Links to Osteogenesis Imperfecta
- Osteogenesis Imperfecta Foundation: The OI Foundation is dedicated to supporting anyone needing information about OI with FREE medically-verified responses to your individual questions.
- Fast facts on Osteogenesis Imperfecta
- Caring for Infants with Osteogenesis Imperfecta
- Osteogenesis Imperfecta Overview: From the NIH