Osteogenesis Impefecta Definition Osteogenesis imperfecta (OI) is a genetic disorder characterized by bones that break easily, often from little or no apparent cause. There are at least four recognized forms of the disorder, representing...

Paget's Disease of Bone What is Paget's disease of bone? Paget's disease is a chronic disorder that typically results in enlarged and deformed bones. The excessive breakdown and formation of bone tissue that occurs with Paget's disease can...

Spina Bifida Table of Contents What is Spina Bifida? Is there any treatment? What is the prognosis? What research is being done? Organizations What is Spina Bifida? Spina bifida (SB) is a neural tube defect (a disorder involving incomplete...

Table of Contents Introduction What is Cerebral Palsy? What Other Medical Disorders? What Causes Cerebral Palsy? What are the Risk Factors? What Are the Early Signs? How is Cerebral Palsy Diagnosed? How is Cerebral Palsy Managed? What Specific...

Hydrocephalus What is Hydrocephalus? Hydrocephalus is a condition in which the primary characteristic is excessive accumulation of fluid in the brain. Although hydrocephalus was once known as "water on the brain," the "water" is actually...

Epidermolysis Bullosa The characteristic feature of epidermolysis bullosa (EB) is blistering in the skin. Some forms of the disease may involve the gastrointestinal tract, the pulmonary system, muscle, or the bladder. Most forms are evident at...

Epilepsy Epilepsy is a brain disorder in which clusters of nerve cells, or neurons, in the brain sometimes signal abnormally. In epilepsy, the normal pattern of neuronal activity becomes disturbed, causing strange sensations, emotions, and...

Endocrine-Metabolic Diseases Acromegaly Acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone (GH). It most commonly affects middle-aged adults and can result in serious illness and premature...

Ehlers-Danlos Syndrome Ehlers-Danlos Syndrome The problems present in Ehlers-Danlos syndrome (EDS), a group of approximately 10 disorders, include changes in the physical properties of skin, joints, blood vessels, and other tissues such as...

Congenital Heart Diseases Congenital heart diseases are abnormalities of the heart's structure and function caused by abnormal or disordered heart development before birth. Congenital heart disease (CHD) is a broad term that can describe a...