Stable Neurodevelopment Seen for Most Children with Familial High Risk for Schizophrenia

Most children at familial high risk for schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) have stable neurocognitive development, but some transition to a different, usually more impaired, subgroup, according to a study published online Oct. 6 in Schizophrenia Bulletin. Christina Bruun Knudsen, from Aarhus University Hospital-Psychiatry in Denmark, and colleagues examined transitions between neurocognitive subgroups among children at FHR-SZ or FHR-BP from age 7 to 11 years in a latent profile analysis that was used to identify subgroups at two assessments based on performance of 320 children across eight neurocognitive functions. Temporal stability in subgroup membership was examined. A reference group of population-based controls was included (199 at age 7 years; 178 at age 11 years). Read More