NASET News Alert

Upper Airway Stimulation Effective in Teens with Down Syndrome

May 06, 2022

For adolescents with Down syndrome and severe obstructive sleep apnea (OSA), upper airway stimulation is safe and effective, according to a study published online April 21 in JAMA Otolaryngology-Head & Neck Surgery. Phoebe K. Yu, M.D., M.P.H., from Massachusetts Eye and Ear in Boston, and colleagues examined the safety and effectiveness of upper airway stimulation for adolescents with Down syndrome and severe OSA in a prospective single-group cohort study. Data were included for 42 adolescents with persistent severe OSA after adenotonsillectomy. The researchers observed a mean decrease in the apnea-hypopnea index (AHI) of 12.9 events/hour among the 42 patients. With use of a therapy response definition of a 50 percent decrease in AHI, the response rate was 65.9 percent at 12 months; 73.2 percent of patients had an AHI of less than 10 events/hour at 12 months. Temporary tongue or oral discomfort was the most common complication (11.9 percent). Read More