This issue of NASET’s Inclusion Series was written by Yasman Cortes, and is a comprehensive literature review exploring strategies supporting students with disabilities in mainstream classrooms. The focus is threefold: examining inclusion practices, identifying evidence-based instructional strategies, and unraveling collaborative partnerships between educators and families. Studies by Rivera & McKeithan (2021), Weiss et al. (2018), and Connor & Cavendish (2018) showcase the crucial role of educators, emphasizing High-Leverage Practices, leadership skills, and understanding student perspectives. Garcia-Melgar et al. (2022), Woods et al. (2018), and Duppong et al. (2019) emphasize collaborative teamwork’s importance, shedding light on factors influencing successful inclusion. The synthesis provides valuable insights for educators, administrators, policymakers, and researchers, offering a roadmap for enhancing inclusive education practices to meet the diverse needs of all students.