NASET News Alert

New Insight into how Autism Might Develop in Human Brain

July 05, 2018

In a study published in Stem Cell Reports, a McGill team of scientists led by Dr. Carl Ernst, researcher at the Douglas Hospital Research Centre, revealed a molecular mechanism that may play a role in the development of autism. By taking skin cells from patients and reprogramming those cells to become brain cells through genetic engineering, Dr. Ernst, graduate student Scott Bell, and Edward A. Fon and Thomas M. Durcan, colleagues at the Montreal Neurological Institute and Hospital, tracked how a brain cell with the patient's own mutation develops improperly. The team focused on a gene named GRIN2B, a gene known to cause autism when mutated. Almost all genes in humans have two copies. A mutation in one copy of GRIN2B is sufficient to cause moderate intellectual disability and autism. Read More

 

 

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